目的：瞭解澳門某醫院慢性疲勞求診者的慢性疲勞的相關生活影響因素。方法：收集387名自覺有疲勞症狀而求診的患者之生活相關資料，並結合疲勞量表-14（FS-14）與慢性疲勞綜合徵（CFS）診斷標準評估疲勞程度以及影響疲勞的相關生活因素。結果：疲勞程度中，中度疲勞所占比例最高，其次是疲勞程度達CFS診斷標準者。影響疲勞的相關生活因素中，65歲以上長者疲勞分數最高，喪偶者疲勞分數高於其它婚姻狀態者，此兩因素呈統計意義差異。女性、有家庭照顧需求者，以及教育程度越低者，疲勞分數有較高的趨勢，但未達統計差異。職業別、工作年齡及每日工作時間的疲勞分數則未見有意義的差異。結論：本調查顯示，與澳門某醫院慢性疲勞求診者疲勞程度相關的主要生活因素為年齡增加及喪偶。雖因樣本來源的侷限性，導致喪偶者例數少，或許無法代表澳門所有人群情況，但基於慢性疲勞相關危險因素的趨勢，亦可提供預防及治療策略參考依據。

Objective: To investigate the related risk life-factors of chronic fatigue in Macao hospital patients. Method: Collect the life-related data of 387 respondents and use the Fatigue Scale-14 (FS-14) and diagnostic criteria for chronic fatigue syndrome (CFS) to assess the level and the related risk life-factors of fatigue. Results: The proportion of moderate fatigue is the highest, followed is the level of fatigue reaching the CFS diagnostic criteria. Among the related life-factors affecting fatigue, people over 65 have the highest fatigue scores; compare to other marital statuses, the fatigue scores are the highest in widow/widower, and these two factors are statistically significant. Females, having care needs in family, and people with lower education levels tend to have higher fatigue scores, but they do not reach statistical significance. There were no significant differences in fatigue scores in occupation, working years, and daily working hours. Conclusion: This study revealed that the level of fatigue increases related to aging and widowhood in Macao hospital patients. The number of widows is small due to the sample source's limitation and it may not represent all the population in Macau. Based on the trend of chronic fatigue-related risk factors, the finding can also provide a reference for prevention and treatment strategies.